![]() Consequently, cyclic ion mobility is incorrectly perceived as a targeted approach that requires preselection of ions prior to separation. However, the quality of the separation may be obfuscated when “wrap-around” occurs, during which speedier ions catch up with slower ion populations when allowed to travel through more than one pass. ![]() The cyclic geometry of the ion mobility cell enables ions to travel multiple passes, increasing their drift times to the detector and relative separation. ![]() Gas chromatography multiplexed with cyclic ion mobility mass spectrometry is a comprehensive two-dimensional separation technique that can resolve compounds that would otherwise coelute in a single-dimension separation.
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